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1

Estimating the starting dose for entry into humans: principles and practice

Bruno G. Reigner, Karen Blesch

Journal:

European Journal of Clinical Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 158 KB

english, 2002

2

Prediction of Hepatic Metabolic Clearance Based on Interspecies Allometric Scaling Techniques andIn Vitro-In VivoCorrelations

Dr Thierry Lavé, Philippe Coassolo, Bruno Reigner

Journal:

Clinical Pharmacokinetics

Année:

1999

Langue:

english

Fichier:

PDF, 277 KB

english, 1999

3

Saturable rate of cefatrizine absorption after oral administration to humans

Bruno G. Reigner, William Couet, Jean-Paul Guedes, Jean-Bernard Fourtillan, Thomas N. Tozer

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1990

Langue:

english

Fichier:

PDF, 883 KB

english, 1990

4

Pediatric Dosing of Ganciclovir and Valganciclovir: How Model-based Simulations Can Prevent Underexposure and Potential Treatment Failure

Jorga, Karin, Reigner, Bruno, Chavanne, Clarisse, Alvaro, Giuseppe, Frey, Nicolas

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 850 KB

english, 2018

5

Pharmacokinetic concepts in assessing intake of pentachlorophenol by rats after exposure through drinking water

Bruno G. Reigner, Ramon A. Gungon, Frederic Y. Bois, Lauren Zeise, Thomas N. Tozer

Journal:

Journal of Pharmaceutical Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 616 KB

english, 1992

6

Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients

Ronald Gieschke, Hans-Ulrich Burger, Bruno Reigner, Karen S. Blesch, Jean-Louis Steimer

Journal:

British Journal of Clinical Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 392 KB

english, 2003

7

In Situ Thrombolysis for Late Occlusion of Suprafemoral Prosthetic Grafts

Bernard Enon, Bruno Reigner, François Lescalié, Philippe l'Hoste, Michel Peret, Jean-Michel Chevalier

Journal:

Annals of Vascular Surgery

Année:

1993

Langue:

english

Fichier:

PDF, 471 KB

english, 1993

8

Transthoracic Endoscopy for Upper Thoracic Chemical Sympathectomy

Eustathios Bardaxoglou, Bruno Reigner, Bernard Enon, Nicolas Tolstuchow, François Lescalié, Michel Peret, Jean-Michel Chevalier

Journal:

Annals of Vascular Surgery

Année:

1992

Langue:

english

Fichier:

PDF, 266 KB

english, 1992

9

Eversion Endarterectomy of the Internal Carotid Artery: Midterm Results of a New Technique

Bruno Reigner, Philippe Reveilleau, Muriel Gayral, Xavier Papon, Bernard Enon, Jean-Michel Chevalier

Journal:

Annals of Vascular Surgery

Année:

1995

Langue:

english

Fichier:

PDF, 458 KB

english, 1995

10

Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients

Christopher Poole, Jill Gardiner, Chris Twelves, Patrick Johnston, Peter Harper, Jim Cassidy, Jayne Monkhouse, Ludger Banken, Erhard Weidekamm, Bruno Reigner

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 128 KB

english, 2002

11

Pharmacokinetics of capecitabine (Xeloda) in Japanese and Caucasian patients with breast cancer

Bruno Reigner, Toru Watanabe, Johannes Schüller, Helen Lucraft, Yasutsuna Sasaki, John Bridgewater, Toshiaki Saeki, James McAleer, Masaru Kuranami, Christopher Poole, Mitsunori Kimura, Jayne Monkhouse

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 243 KB

english, 2003

12

Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients

Johannes Schüller, Jim Cassidy, Etienne Dumont, Brigitte Roos, Sarah Durston, Ludger Banken, Masahiro Utoh, Kazushige Mori, Erhard Weidekamm, Bruno Reigner

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 106 KB

english, 2000

13

Influence of the antacid Maalox on the pharmacokinetics of capecitabine in cancer patients

Bruno Reigner, Saly Clive, Jim Cassidy, Duncan Jodrell, Rainer Schulz, Timothy Goggin, Ludger Banken, Brigitte Roos, Masahiro Utoh, Thomas Mulligan, Erhard Weidekamm

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 114 KB

english, 1999

14

Bioequivalence of two tablet formulations of capecitabine and exploration of age, gender, body surface area, and creatinine clearance as factors influencing systemic exposure in cancer patients

Jim Cassidy, Chris Twelves, David Cameron, William Steward, Ken O'Byrne, Duncan Jodrell, Ludger Banken, Timothy Goggin, David Jones, Brigitte Roos, Erine Bush, Erhard Weidekamm, Bruno Reigner

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 185 KB

english, 1999

15

Simultaneous assay of pentachlorophenol and its metabolite, tetrachlorohydroquinone, by gas chromatography without derivatization

Bruno G. Reigner, Jean F. Rigod, Thomas N. Tozer

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1990

Langue:

english

Fichier:

PDF, 926 KB

english, 1990

16

A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug

Ian R. Judson, Philip J. Beale, José M. Trigo, Wynne Aherne, Thomas Crompton, David Jones, Ernie Bush, Bruno Reigner

Journal:

Investigational New Drugs

Année:

1999

Langue:

english

Fichier:

PDF, 107 KB

english, 1999

17

Disposition, Bioavailability, and Serum Protein Binding of Pentachlorophenol in the B6C3F1 Mouse

Bruno G. Reigner, Jean F. Rigod, Thomas N. Tozer

Journal:

Pharmaceutical Research

Année:

1992

Fichier:

PDF, 905 KB

1992

18

Theoretical model for both saturable rate and extent of absorption: Simulations of cefatrizine data

William R. Couet, Bruno G. Reigner, Jean-Paul Guedes, Thomas N. Tozer

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1991

Langue:

english

Fichier:

PDF, 516 KB

english, 1991

19

Effect of hemodialysis and hemofiltration on plasma C.E.R.A. concentrations

John K. Leypoldt, Mahmoud Loghman-Adham, Paul Jordan, Bruno Reigner

Journal:

Hemodialysis International

Année:

2012

Langue:

english

Fichier:

PDF, 459 KB

english, 2012

20

An Evaluation of the Integration of Pharmacokinetic and Pharmacodynamic Principles in Clinical Drug Development

Dr Bruno G. Reigner, Peter E. O. Williams, Indra H. Patel, Jean-Louis Steimer, Carl Peck, Peter van Brummelen

Journal:

Clinical Pharmacokinetics

Année:

1997

Langue:

english

Fichier:

PDF, 1.06 MB

english, 1997

21

Clinical Pharmacokinetics of Capecitabine

Dr Bruno Reigner, Karen Blesch, Erhard Weidekamm

Journal:

Clinical Pharmacokinetics

Année:

2001

Langue:

english

Fichier:

PDF, 253 KB

english, 2001

22

C.E.R.A.: pharmacodynamics, pharmacokinetics and efficacy in patients with chronic kidney disease

Locatelli, Francesco, Reigner, Bruno

Journal:

Expert Opinion on Investigational Drugs

Année:

2007

Langue:

english

Fichier:

PDF, 218 KB

english, 2007

23

Subcutaneous injection pain with C.E.R.A., a continuous erythropoietin receptor activator, compared with darbepoetin alfa

Pannier, Anne, Jordan, Paul, Dougherty, Frank C., Bour, Fabrice, Reigner, Bruno

Journal:

Current Medical Research and Opinion

Année:

2007

Langue:

english

Fichier:

PDF, 270 KB

english, 2007

24

Bayesian adaptive designs in single ascending dose trials in healthy volunteers

Guédé, David, Reigner, Bruno, Vandenhende, Francois, Derks, Mike, Beyer, Ulrich, Jordan, Paul, Worth, Eric, Diack, Cheikh, Frey, Nicolas, Peck, Richard

Journal:

British Journal of Clinical Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 1003 KB

english, 2014

25

The effect of severe hepatic impairment on the pharmacokinetics and haematological response of C.E.R.A.

Kupčová, Viera, Šperl, Jan, Pannier, Anne, Jordan, Paul, Dougherty, Frank C., Reigner, Bruno

Journal:

Current Medical Research and Opinion

Année:

2008

Langue:

english

Fichier:

PDF, 228 KB

english, 2008

26

Population Pharmacokinetic/Pharmacodynamic Model for C.E.R.A. in Both ESA-Naïve and ESA-Treated Chronic Kidney Disease Patients With Renal Anemia

Chanu, Pascal, Gieschke, Ronald, Charoin, Jean-Eric, Pannier, Anne, Reigner, Bruno

Journal:

Journal of Clinical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 558 KB

english, 2010

27

Pharmacokinetic and Pharmacodynamic Properties of Methoxy Polyethylene Glycol-Epoetin Beta Are Unaffected by the Site of Subcutaneous Administration 1

Fishbane, Steven, Pannier, Anne, Liogier, Xavier, Jordan, Paul, Dougherty, Frank C., Reigner, Bruno

Journal:

Journal of Clinical Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 126 KB

english, 2007

28

Bayesian adaptive dose-escalation procedures for binary and continuous responses utilizing a gain function

Yeung, Wai Yin, Whitehead, John, Reigner, Bruno, Beyer, Ulrich, Diack, Cheikh, Jaki, Thomas

Journal:

Pharmaceutical Statistics

Année:

2015

Langue:

english

Fichier:

PDF, 775 KB

english, 2015

29

Bayesian adaptive dose-escalation designs for simultaneously estimating the optimal and maximum safe dose based on safety and efficacy

Yeung, Wai Yin, Reigner, Bruno, Beyer, Ulrich, Diack, Cheikh, Sabanés bové, Daniel, Palermo, Giuseppe, Jaki, Thomas

Journal:

Pharmaceutical Statistics

Année:

2017

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2017

30

Development of a PBPK Model for Mefloquine and its Application alongside a Clinical Effectiveness Model to Select an Optimal Dose for Prevention of Malaria in Young Caucasian Children

Johnson, Trevor N., Cleary, Yumi, Parrott, Neil, Reigner, Bruno, Smith, James R., Toovey, Stephen

Journal:

British Journal of Clinical Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 814 KB

english, 2018

31

Phase I and Pharmacokinetic Study of the Oral Fluoropyrimidine Capecitabine in Combination With Paclitaxel in Patients With Advanced Solid Malignancies

Villalona-Calero, Miguel A., Weiss, Geoffrey R., Burris, Howard A., Kraynak, Maura, Rodrigues, Gladys, Drengler, Ronald L., Eckhardt, S. Gail, Reigner, Bruno, Moczygemba, Judy, Burger, Hans Ulrich, Gr

Journal:

Journal of Clinical Oncology

Année:

1999

Langue:

english

Fichier:

PDF, 92 KB

english, 1999

32

Model‐based approach for methoxy polyethylene glycol‐epoetin beta drug development in paediatric patients with anaemia of chronic kidney disease [142/999 characters (incl. spaces)]

Chanu, Pascal, Schaefer, Franz, Warady, Bradley A., Schmitt, Claus Peter, Reigner, Bruno, Schnetzler, Gabriel, Meyer Reigner, Sylvie, Eisner, Mark, Weichert, Arlette, Frey, Nicolas

Journal:

British Journal of Clinical Pharmacology

Année:

2019

Fichier:

PDF, 1.04 MB

2019